4-(Methylsulfonamido)aniline → 2-(4-Benzyl-piperidin-1-yl)-N-(4-methanesulfonylamino-phenyl)-2-oxo-acetamide

HRID 2114977Notes

Reaction equation

HRID 2114977 reaction equation
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:18])[C:15]([OH:17])=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([NH:26][S:27]([CH3:30])(=[O:29])=[O:28])=[CH:22][CH:21]=1>O>[CH2:1]([CH:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:18])[C:15]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([NH:26][S:27]([CH3:30])(=[O:29])=[O:28])=[CH:22][CH:21]=2)=[O:17])[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 37325774-(Methylsulfonamido)anilineHCID 16110264(4-Benzylpiperidin-1-yl)oxoacetic acid

Product 1

HCID 102733232-(4-Benzyl-piperidin-1-yl)-N-(4-methanesulfonylamino-phenyl)-2-oxo-acetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared from (4-benzyl-piperidin-1-yl)-oxo-acetic acid (Example 5b) and N-(4-amino-phenyl)-methanesulfonamide [Tetrahedron, 42, 5739. (1986)] according to the method described in Example 2. Melting Point: 221-225° C. (water)

Sources & evidence

ORD record
ord-fe52e375ec2e4ce183a9bb892ca26157
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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