4-[(4-Methylphenyl)methyl]piperidine → 2-[4-(4-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

HRID 2115016Notes

Reaction equation

HRID 2115016 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([NH:12][C:13](=[O:17])[C:14]([OH:16])=O)=[CH:11][C:5]=2[O:4][CH2:3]1.[CH3:18][C:19]1[CH:31]=[CH:30][C:22]([CH2:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:21][CH:20]=1>C(OCC)C>[CH3:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][CH:24]2[CH2:29][CH2:28][N:27]([C:14](=[O:16])[C:13]([NH:12][C:10]3[CH:9]=[CH:8][C:6]4[NH:7][C:2](=[O:1])[CH2:3][O:4][C:5]=4[CH:11]=3)=[O:17])[CH2:26][CH2:25]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 33756034-[(4-Methylphenyl)methyl]piperidineHCID 69100554N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid

Product 1

HCID 443930252-[4-(4-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid (Example 53b) and 4-(4-methylbenzyl)-piperidine [J Org. Chem., 64,3763. (1999)] according to the method described in Example 1c. Melting Point: 228-231° C. (diethylether)

Sources & evidence

ORD record
ord-5887b70dbac54b4fb1ad77ed09c1aeaa
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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