4-[(4-Methylphenyl)methyl]piperidine → 2-[4-(4-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Participants

Role	Name	HCID	Charge
Reactant	4-[(4-Methylphenyl)methyl]piperidine	HCID 3375603	—
Reactant	N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid	HCID 69100554	—
Solvent	Diethyl Ether	HCID 3283	—
Product	2-[4-(4-Methyl-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide	HCID 44393025	—

Reaction Steps

The title compound is prepared from N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid (Example 53b) and 4-(4-methylbenzyl)-piperidine [J Org. Chem., 64,3763. (1999)] according to the method described in Example 1c. Melting Point: 228-231° C. (diethylether)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07435744B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-5887b70dbac54b4fb1ad77ed09c1aeaa
Source note	uspto-grants-2008_10