Diethyl Ether → 2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-acetamide

HRID 2115023Notes

Reaction equation

HRID 2115023 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)=[CH:10][C:4]=2[S:3]1.[Cl:17][C:18]1[CH:30]=[CH:29][C:21](CC2CCNCC2)=[CH:20][CH:19]=1.C([O:33][CH2:34][CH3:35])C>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([O:33][CH:34]2[CH2:35][CH2:2][N:6]([C:13](=[O:15])[C:12]([NH:11][C:9]3[CH:8]=[CH:7][C:5]4[NH:6][C:2](=[O:1])[S:3][C:4]=4[CH:10]=3)=[O:16])[CH2:5][CH2:4]2)=[CH:29][CH:30]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 37327804-(4-Chlorobenzyl)piperidineHCID 53306726N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-oxalamic acid

Product 1

HCID 101376412-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-acetamide

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-benzothiazol-6-yl)-oxalamic acid (Example 61b) and 4-(4-chloro-benzyl)-piperidine according to the method described in Example 1c. Melting Point: 245-247° C. (diethylether)

Sources & evidence

ORD record
ord-33c6d3f6510246638d6eb0a8d01b748f
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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