3-(Trifluoromethyl)aniline → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-trifluoromethyl-phenyl)-acetamide

HRID 2115047Notes

Reaction equation

HRID 2115047 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:17])[C:14]([OH:16])=O)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[F:20][C:21]([F:30])([F:29])[C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25]>C(OCC)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([C:13](=[O:17])[C:14]([NH:25][C:24]3[CH:26]=[CH:27][CH:28]=[C:22]([C:21]([F:20])([F:29])[F:30])[CH:23]=3)=[O:16])[CH2:11][CH2:12]2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

Product 1

HCID 691002322-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-trifluoromethyl-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from [4-(4-fluoro-benzyl)-piperidine-1-yl]-oxo-acetic acid (Example 1b) and 3-(trifluoromethyl)-aniline (Aldrich) according to the method described in Example 94. Melting Point: 113-115° C. (diethylether

Sources & evidence

ORD record
ord-ebea8b5d34494cf4a5a94c8619f8c11d
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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