HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)aniline → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-trifluoromethyl-phenyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Reactant | [4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid | HCID 51342220 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-trifluoromethyl-phenyl)-acetamide | HCID 69100232 | — |
Reaction Steps
The title compound is prepared from [4-(4-fluoro-benzyl)-piperidine-1-yl]-oxo-acetic acid (Example 1b) and 3-(trifluoromethyl)-aniline (Aldrich) according to the method described in Example 94. Melting Point: 113-115° C. (diethylether
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-ebea8b5d34494cf4a5a94c8619f8c11d |
| Source note | uspto-grants-2008_10 |