1-Methyl-4-phenoxypiperidine → 2-Oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-2-(4-phenoxymethyl-piperidin-1-yl)-acetamide

HRID 2115056Notes

Reaction equation

HRID 2115056 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)[CH:8]=2)[NH:3]1.[O:17]([CH:24]1[CH2:29][CH2:28]N(C)CC1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(OCC)C>[O:15]=[C:13]([N:3]1[CH2:4][CH2:28][CH:29]([CH2:24][O:17][C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:10][CH2:2]1)[C:12]([NH:11][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[NH:3][C:2](=[O:1])[CH2:10]2)=[O:16]

Participants

4

Reactant 2

HCID 187229981-Methyl-4-phenoxypiperidineHCID 53306725N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-oxalamic acid

Product 1

HCID 691007172-Oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-2-(4-phenoxymethyl-piperidin-1-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-oxalamic acid (Example 101b) and 4-phenoxy-methyl-piperidine according to the method described in Example 1c. Melting Point: 200-202° C. (diethylether)

Sources & evidence

ORD record
ord-4b7438d3a02e4b0e825e243fbf3c2024
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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