4-((4-Methoxyphenyl)methyl)piperidine → 2-{4-[(4-Methoxyphenyl)methyl]piperidin-1-yl}-2-oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)acetamide

HRID 2115057Notes

Reaction equation

HRID 2115057 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:11][C:12](=[O:16])[C:13]([OH:15])=O)[CH:8]=2)[NH:3]1.[CH3:17][O:18][C:19]1[CH:31]=[CH:30][C:22]([CH2:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:21][CH:20]=1>C(OCC)C>[CH3:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][CH:24]2[CH2:25][CH2:26][N:27]([C:13](=[O:15])[C:12]([NH:11][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[NH:3][C:2](=[O:1])[CH2:10]4)=[O:16])[CH2:28][CH2:29]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 37327404-((4-Methoxyphenyl)methyl)piperidineHCID 53306725N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-oxalamic acid

Product 1

HCID 691004672-{4-[(4-Methoxyphenyl)methyl]piperidin-1-yl}-2-oxo-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-oxalamic acid (Example 101b) and 4-(4-methoxy-benzyl)-piperidine [U.S. Pat. No. 3,632,767 (1972)] according to the method described in Example 1c. Melting Point: 215-217° C. (diethylether)

Sources & evidence

ORD record
ord-678d1c6706b649d0bf2cc0bc0bf50c29
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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