4-[(4-Fluorophenyl)methyl]piperidine hydrochloride → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide

HRID 2115076Notes

Reaction equation

HRID 2115076 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10](=[O:15])[CH2:9]2)=[O:4].Cl.[F:17][C:18]1[CH:30]=[CH:29][C:21]([CH2:22][CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:20][CH:19]=1>C(OCC)C>[F:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][CH:23]2[CH2:24][CH2:25][N:26]([CH2:2][C:3]([NH:5][C:6]3[CH:7]=[C:8]4[C:12](=[CH:13][CH:14]=3)[NH:11][C:10](=[O:15])[CH2:9]4)=[O:4])[CH2:27][CH2:28]2)=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochlorideHCID 53310272HCID 53310272, compound

Product 1

HCID 691007552-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(2-oxo-2,3-dihydro-1H-indol-5-yl)acetamide (Example 143a) and 4-(4-fluoro-benzyl)-piperidine hydrochloride according to the method described in Example 142b. Melting Point: 178-180° C. (diethylether)

Sources & evidence

ORD record
ord-ec0c7b7634194388aad55571ddeb28cc
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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