4-Benzylpiperidine → 2-(4-Benzyl-piperidin-1-yl)-N-(4-cyano-phenyl)-acetamide

HRID 2115077Notes

Reaction equation

HRID 2115077 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1)=[O:4].[CH2:14]([CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(OCC)C>[CH2:14]([CH:21]1[CH2:26][CH2:25][N:24]([CH2:2][C:3]([NH:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=2)=[O:4])[CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 317384-BenzylpiperidineHCID 21680152-chloro-N-(4-cyanophenyl)acetamide

Product 1

HCID 23998222-(4-Benzyl-piperidin-1-yl)-N-(4-cyano-phenyl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(4-cyano-phenyl)-acetamide [J. Org. Chem., 23, 141. (1958)] and 4-benzyl-piperidine according to the method described in Example 142b. Melting Point: 120-124° C. (diethylether)

Sources & evidence

ORD record
ord-99df957614d346798c30844297576b93
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

Loading…