4-(4-Fluoro-benzyl)-piperidine → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(1H-indazol-5-yl)-acetamide

HRID 2115080Notes

Reaction equation

HRID 2115080 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[NH:11][N:10]=[CH:9]2)=[O:4].[F:15][C:16]1[CH:28]=[CH:27][C:19]([CH2:20][CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:18][CH:17]=1>C(OCC)C>[F:15][C:16]1[CH:17]=[CH:18][C:19]([CH2:20][CH:21]2[CH2:22][CH2:23][N:24]([CH2:2][C:3]([NH:5][C:6]3[CH:7]=[C:8]4[C:12](=[CH:13][CH:14]=3)[NH:11][N:10]=[CH:9]4)=[O:4])[CH2:25][CH2:26]2)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 171644632-chloro-N-(1H-indazol-5-yl)acetamide

Product 1

HCID 691006572-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(1H-indazol-5-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(1H-indazol-5-yl)-acetamide (Example 147a) and 4-(4-fluoro-benzyl)-piperidine according to the method described in Example 142b. Melting Point: 149-152° C. (diethylether)

Sources & evidence

ORD record
ord-9eea7a3a6b3f4a14bfd99619a51fa6f1
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

Loading…