4-(4-Fluoro-benzyl)-piperidine → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

HRID 2115086Notes

Reaction equation

HRID 2115086 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:16]=[CH:15][C:9]2[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=2[CH:7]=1)=[O:4].[F:17][C:18]1[CH:30]=[CH:29][C:21]([CH2:22][CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[CH:20][CH:19]=1>C(OCC)C>[F:17][C:18]1[CH:19]=[CH:20][C:21]([CH2:22][CH:23]2[CH2:24][CH2:25][N:26]([CH2:2][C:3]([NH:5][C:6]3[CH:16]=[CH:15][C:9]4[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=4[CH:7]=3)=[O:4])[CH2:27][CH2:28]2)=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 242982822-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Product 1

HCID 691002912-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide (Example 153a) and 4-(4-fluoro-benzyl)-piperidine according to the method described in Example 142b. Melting Point: 209-211° C. (diethylether)

Sources & evidence

ORD record
ord-68f389801e9649e7a9106d53daeda47f
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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