4-(2-Phenylethyl)piperidine → 2-(4-Phenethyl-piperidin-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide

HRID 2115092Notes

Reaction equation

HRID 2115092 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:16]=[CH:15][C:9]2[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=2[CH:7]=1)=[O:4].[CH2:17]([CH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1)[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(OCC)C>[CH2:17]([CH:25]1[CH2:26][CH2:27][N:28]([CH2:2][C:3]([NH:5][C:6]2[CH:16]=[CH:15][C:9]3[NH:10][C:11](=[O:14])[CH2:12][O:13][C:8]=3[CH:7]=2)=[O:4])[CH2:29][CH2:30]1)[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 43418954-(2-Phenylethyl)piperidineHCID 242982822-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-acetamide

Product 1

HCID 691006492-(4-Phenethyl-piperidin-1-yl)-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide (Example 153a) and 4-phenethyl-piperidine according to the method described in Example 142b. Melting Point: 200-203° C. (diethylether)

Sources & evidence

ORD record
ord-6bb7b93428fd46cba9d9846b3c8177dd
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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