2-chloro-N-(4-cyanophenyl)acetamide → N-(4-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetamide

HRID 2115097Notes

Reaction equation

HRID 2115097 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1)=[O:4].Cl.[F:15][C:16]1[CH:28]=[CH:27][C:19]([CH2:20][CH:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:18][CH:17]=1>C(OCC)C>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([NH:5][C:3](=[O:4])[CH2:2][N:24]2[CH2:25][CH2:26][CH:21]([CH2:20][C:19]3[CH:18]=[CH:17][C:16]([F:15])=[CH:28][CH:27]=3)[CH2:22][CH2:23]2)=[CH:7][CH:8]=1)#[N:13]

Participants

4

Reactant 2

HCID 21680152-chloro-N-(4-cyanophenyl)acetamideHCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochloride

Product 1

HCID 69100319N-(4-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(4-cyano-phenyl)-acetamide and 4-(4-fluoro-benzyl)-piperidine hydrochloride according to the method described in Example 142b. Melting Point: 113-116° C. (diethylether)

Sources & evidence

ORD record
ord-22ee9e8c71ba410f902c0357d2ec8a9f
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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