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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2115097Generated: October 30, 2026

2-chloro-N-(4-cyanophenyl)acetamide → N-(4-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetamide

https://huagongshe.com/reaction/2115097

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-chloro-N-(4-cyanophenyl)acetamideHCID 2168015—
Reactant4-[(4-Fluorophenyl)methyl]piperidine hydrochlorideHCID 17039492—
SolventDiethyl EtherHCID 3283—
ProductN-(4-Cyano-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetamideHCID 69100319—

Reaction Steps

The title compound is prepared from 2-chloro-N-(4-cyano-phenyl)-acetamide and 4-(4-fluoro-benzyl)-piperidine hydrochloride according to the method described in Example 142b. Melting Point: 113-116° C. (diethylether)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07435744B2
Source datasetuspto-grants-2008_10
ORD IDord-22ee9e8c71ba410f902c0357d2ec8a9f
Source noteuspto-grants-2008_10