Diethyl Ether → 1-Piperidineacetamide,4-[(4-fluorophenyl)methyl]-n-(3-nitrophenyl)-

HRID 2115105Notes

Reaction equation

HRID 2115105 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)=[O:4].Cl.[F:16][C:17]1[CH:29]=[CH:28][C:20]([CH2:21]N2CCCCC2)=[CH:19][CH:18]=1.C(O[CH2:33][CH3:34])C>>[F:16][C:17]1[CH:18]=[CH:19][C:20]([CH2:21][CH:34]2[CH2:33][CH2:6][N:5]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=3)=[O:4])[CH2:3][CH2:2]2)=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 5320662-chloro-N-(3-nitrophenyl)acetamideHCID 225574574-Fluoro-benzyl-piperidine hydrochloride

Product 1

HCID 691003571-Piperidineacetamide,4-[(4-fluorophenyl)methyl]-n-(3-nitrophenyl)-

Procedure

The title compound is prepared from 2-chloro-N-(3-nitrophenyl)-acetamide and 4-(4-fluoro-benzyl-piperidine hydrochloride according to the method described in Example 142b. Melting Point: 118-120° C. (diethylether)

Sources & evidence

ORD record
ord-60935b6c69194d75ac8c89d566fe79f9
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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