4-[(4-Fluorophenyl)methyl]piperidine hydrochloride → 1-Piperidineacetamide,4-[(4-fluorophenyl)methyl]-n-[4-[(methylsulfonyl)amino]phenyl]-

HRID 2115107Notes

Reaction equation

HRID 2115107 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)=[O:4].Cl.[F:18][C:19]1[CH:31]=[CH:30][C:22]([CH2:23][CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:21][CH:20]=1>CCCCCC>[F:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][CH:24]2[CH2:25][CH2:26][N:27]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[CH:10][C:9]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=3)=[O:4])[CH2:28][CH2:29]2)=[CH:30][CH:31]=1

Participants

4

Reactant 2

HCID 170394924-[(4-Fluorophenyl)methyl]piperidine hydrochlorideHCID 433470892-chloro-N-[4-(methanesulfonamido)phenyl]acetamide

Product 1

HCID 691005561-Piperidineacetamide,4-[(4-fluorophenyl)methyl]-n-[4-[(methylsulfonyl)amino]phenyl]-

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

The title compound is prepared from 2-chloro-N-(4-methanesulfonylamino-phenyl)-acetamide (Example 180a) and 4-(4-fluoro-benzyl)-piperidine hydrochloride according to the method described in Example 142b. Melting Point: 169-171° C. (hexane)

Sources & evidence

ORD record
ord-ecc6ae2e948a4e7e928058c1da64fada
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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