4-(Methyl-p-tolyl-amino)-piperidine → 1-Piperidineacetamide,4-[methyl(4-methylphenyl)amino]-n-[4-[(methylsulfonyl)amino]phenyl]-

HRID 2115108Notes

Reaction equation

HRID 2115108 reaction equation
C([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([NH:24][S:25]([CH3:28])(=[O:27])=[O:26])=[CH:20][CH:19]=2)=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[CH3:29][N:30]([C:37]1[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=1)C1CCNCC1>C(OCC)C>[CH3:28][S:25]([NH:24][C:21]1[CH:20]=[CH:19][C:18]([NH:17][C:15](=[O:16])[CH2:14][N:11]2[CH2:10][CH2:9][CH:8]([N:30]([CH3:29])[C:37]3[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=3)[CH2:13][CH2:12]2)=[CH:23][CH:22]=1)(=[O:26])=[O:27]

Participants

4

Reactant 2

HCID 619810154-(Methyl-p-tolyl-amino)-piperidineHCID 690999751-Piperidineacetamide,n-[4-[(methylsulfonyl)amino]phenyl]-4-(phenylmethyl)-

Product 1

HCID 691010101-Piperidineacetamide,4-[methyl(4-methylphenyl)amino]-n-[4-[(methylsulfonyl)amino]phenyl]-

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-N-(4-methanesulfonylamino-phenyl)-acetamide (Example 180) and 4-(methyl-p-tolyl-amino)-piperidine [Arzneimittel Forschung/Drug Research 44(II), 989. (19994)]) according to the method described in Example 142b. Melting Point: 128-130° C. (diethylether)

Sources & evidence

ORD record
ord-92ad52f871c54b6499ca851957b17b87
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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