Methanesulfonyl chloride → HCID 69100720, compound

HRID 2115112Notes

Reaction equation

HRID 2115112 reaction equation
Cl.Cl.[NH2:3][C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:27])[CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH2:15][CH2:14]2)[CH:7]=[CH:8][CH:9]=1.[CH3:28][S:29]([Cl:32])(=[O:31])=[O:30]>C(OC(=O)C)C.C(OCC)C>[F:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][CH:16]2[CH2:15][CH2:14][N:13]([CH2:12][C:11]([NH2:10])=[O:27])[CH2:18][CH2:17]2)=[CH:21][CH:22]=1.[ClH:32].[CH3:28][S:29]([NH:3][C:4]1[CH:5]=[C:6]([NH:10][C:11](=[O:27])[CH3:12])[CH:7]=[CH:8][CH:9]=1)(=[O:31])=[O:30]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 69100145HCID 69100145, compound

Product 1

HCID 69100720HCID 69100720, compound

Reagents, catalysts & solvents 1

HCID 21584169Diethylether ethylacetateSolvent

Procedure

The title compound is prepared from N-(3-amino-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-acetamide dihydrochloride (Example 183) and methanesulfonyl chloride according to the method described in Example 176. Melting Point: 85-90° C. (dec.) (diethylether- ethyl acetate)

Sources & evidence

ORD record
ord-d7ecd144e5454f7e9c6acb566533a607
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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