1H-Indazol-5-amine → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(1H-indazol-5-yl-amino)-ethanone

HRID 2115121Notes

Reaction equation

HRID 2115121 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.Cl[CH2:12][C:13]([N:15]1[CH2:20][CH2:19][CH:18]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:17][CH2:16]1)=[O:14]>C(OCC)C>[F:28][C:25]1[CH:26]=[CH:27][C:22]([CH2:21][CH:18]2[CH2:19][CH2:20][N:15]([C:13](=[O:14])[CH2:12][NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[NH:7][N:6]=[CH:5]4)[CH2:16][CH2:17]2)=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 880121H-Indazol-5-amineHCID 691000562-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone

Product 1

HCID 690999761-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(1H-indazol-5-yl-amino)-ethanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 5-aminoindazol (Aldrich) and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 142b. Melting Point: 113-114° C. (diethylether)

Sources & evidence

ORD record
ord-052f4b7caef94229a9d2e1b1dc0f6179
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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