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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2115121Generated: October 29, 2026

1H-Indazol-5-amine → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(1H-indazol-5-yl-amino)-ethanone

https://huagongshe.com/reaction/2115121

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Indazol-5-amineHCID 88012—
Reactant2-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanoneHCID 69100056—
SolventDiethyl EtherHCID 3283—
Product1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(1H-indazol-5-yl-amino)-ethanoneHCID 69099976—

Reaction Steps

The title compound is prepared from 5-aminoindazol (Aldrich) and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 142b. Melting Point: 113-114° C. (diethylether)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07435744B2
Source datasetuspto-grants-2008_10
ORD IDord-052f4b7caef94229a9d2e1b1dc0f6179
Source noteuspto-grants-2008_10