1H-Indazol-5-amine → 1-(4-Benzyl-piperidin-1-yl)-2-(1H-indazol-5-yl-amino)-ethanone

HRID 2115122Notes

Reaction equation

HRID 2115122 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.Cl[CH2:12][C:13]([N:15]1[CH2:20][CH2:19][CH:18]([CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:17][CH2:16]1)=[O:14]>C(OCC)C>[CH2:21]([CH:18]1[CH2:17][CH2:16][N:15]([C:13](=[O:14])[CH2:12][NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][N:6]=[CH:5]3)[CH2:20][CH2:19]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 880121H-Indazol-5-amineHCID 11296081-(4-Benzylpiperidin-1-yl)-2-chloroethan-1-one

Product 1

HCID 691003831-(4-Benzyl-piperidin-1-yl)-2-(1H-indazol-5-yl-amino)-ethanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 5-aminoindazol and 2-chloro-1-(4-benzyl-piperidin-1-yl)-ethanone according to the method described in Example 142b. Melting Point: 153-155° C. (diethylether)

Sources & evidence

ORD record
ord-1a670c8405664bc6b67b2edbd26d5f5c
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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