Diethyl Ether → 2-(4-p-Tolyloxy-piperidin-1-yl)-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl-amino)-ethanone

HRID 2115130Notes

Reaction equation

[NH2:1][C:2]1[CH:12]=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.Cl[CH2:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([O:23][C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)[CH2:19][CH2:18]1)=O.C([O:33]CC)C>>[C:27]1([CH3:30])[CH:28]=[CH:29][C:24]([O:23][CH:20]2[CH2:21][CH2:22][N:17]([CH:15]([NH:1][C:2]3[CH:12]=[CH:11][C:5]4[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=4[CH:3]=3)[CH:14]=[O:33])[CH2:18][CH2:19]2)=[CH:25][CH:26]=1

Participants

Reactant 3

HCID 3283Diethyl Ether

HCID 27641827-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one

HCID 691003022-Chloro-1-(4-p-tolyloxy-piperidin-1-yl) ethanone

Product 1

HCID 865939342-(4-p-Tolyloxy-piperidin-1-yl)-2-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl-amino)-ethanone

Procedure

The title compound is prepared from 7-amino-4H-benzo[1,4]oxazin-3-one and 2-chloro-1-(4-p-tolyloxy-piperidin-1-yl) ethanone (Example 208a) according to the method described in Example 206. Melting Point: 223-224° C. (diethylether)

Sources & evidence

ORD record: ord-d1e2f6f4283f47d4bbd295a663b9aa74
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435744B2

Reaction notes

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