2(3H)-Benzothiazolone, 6-amino- → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(2-oxo-2,3-dihydro-benzothiazol-6-yl-amino)-ethanone

HRID 2115131Notes

Reaction equation

HRID 2115131 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[O:9])[S:8][C:4]=2[CH:3]=1.Cl[CH2:13][C:14]([N:16]1[CH2:21][CH2:20][CH:19]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=2)[CH2:18][CH2:17]1)=[O:15]>C(OCC)C>[F:29][C:26]1[CH:27]=[CH:28][C:23]([CH2:22][CH:19]2[CH2:20][CH2:21][N:16]([C:14](=[O:15])[CH2:13][NH:1][C:2]3[CH:11]=[CH:10][C:5]4[NH:6][C:7](=[O:9])[S:8][C:4]=4[CH:3]=3)[CH2:17][CH2:18]2)=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 64533292(3H)-Benzothiazolone, 6-amino-HCID 691000562-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone

Product 1

HCID 691000481-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(2-oxo-2,3-dihydro-benzothiazol-6-yl-amino)-ethanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 6-amino-3H-benzothiazol-2-one and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 206. Melting Point: 149-155° C. (diethylether)

Sources & evidence

ORD record
ord-991911cbfaef4c66b58f21183ae86377
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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