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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2115135Generated: October 30, 2026

P-Anisidine → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(4-methoxy-phenylamino)-ethanone

https://huagongshe.com/reaction/2115135

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-AnisidineHCID 7732—
ReactantDiisopropyl EtherHCID 7914—
Reactant2-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanoneHCID 69100056—
Product1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(4-methoxy-phenylamino)-ethanoneHCID 69100196—

Reaction Steps

The title compound is prepared from 4-methoxy-aniline (Aldrich) and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 206. Melting Point: 141-143° C. (diisopropylether)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07435744B2
Source datasetuspto-grants-2008_10
ORD IDord-1e60880022694f99834c373ea3c72fe0
Source noteuspto-grants-2008_10