P-Anisidine → 1-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(4-methoxy-phenylamino)-ethanone

HRID 2115135Notes

Reaction equation

HRID 2115135 reaction equation
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.Cl[CH2:11][C:12]([N:14]1[CH2:19][CH2:18][CH:17]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH2:16][CH2:15]1)=[O:13].C(OC(C)C)(C)C>>[F:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][CH:17]2[CH2:18][CH2:19][N:14]([C:12](=[O:13])[CH2:11][NH:7][C:6]3[CH:8]=[CH:9][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:15][CH2:16]2)=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 7732P-AnisidineHCID 7914Diisopropyl EtherHCID 691000562-Chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone

Product 1

HCID 691001961-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-(4-methoxy-phenylamino)-ethanone

Procedure

The title compound is prepared from 4-methoxy-aniline (Aldrich) and 2-chloro-1-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanone (Example 197a) according to the method described in Example 206. Melting Point: 141-143° C. (diisopropylether)

Sources & evidence

ORD record
ord-1e60880022694f99834c373ea3c72fe0
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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