1-(4-Benzylpiperidin-1-yl)-2-chloroethan-1-one → 6-[2-(4-Benzyl-piperidin-1-yl)-2-oxo-ethylamino]-3,4-dihydro-1H-quinolin-2-one

HRID 2115142Notes

Reaction equation

HRID 2115142 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]2.Cl[CH2:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:19][CH2:18]1)=[O:16]>C(O)C>[CH2:23]([CH:20]1[CH2:19][CH2:18][N:17]([C:15](=[O:16])[CH2:14][NH:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[NH:8][C:7](=[O:12])[CH2:6][CH2:5]3)[CH2:22][CH2:21]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 11296081-(4-Benzylpiperidin-1-yl)-2-chloroethan-1-oneHCID 49127596-amino-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 691002296-[2-(4-Benzyl-piperidin-1-yl)-2-oxo-ethylamino]-3,4-dihydro-1H-quinolin-2-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound is prepared from 6-amino-3,4-dihydro-1H-quinoline-2-one and 2-chloro-1-(4-benzyl-piperidin-1-yl)-ethanone (Example 200a) according to the method described in Example 206. Melting Point: 184-187° C. (ethanol)

Sources & evidence

ORD record
ord-671cf0695f374d9489128a9f690b7e87
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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