5-Amino-2-hydroxybenzimidazole → 5-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-1,3-dihydro-benzoimidazol-2-one

HRID 2115145Notes

Reaction equation

HRID 2115145 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.Cl[CH2:13][C:14]([N:16]1[CH2:21][CH2:20][CH:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[CH2:18][CH2:17]1)=[O:15]>C(OCC)C>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([O:22][CH:19]2[CH2:18][CH2:17][N:16]([C:14](=[O:15])[CH2:13][NH:1][C:2]3[CH:11]=[CH:10][C:5]4[NH:6][C:7](=[O:9])[NH:8][C:4]=4[CH:3]=3)[CH2:21][CH2:20]2)=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 667655-Amino-2-hydroxybenzimidazoleHCID 691000112-Chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone

Product 1

HCID 691003905-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-1,3-dihydro-benzoimidazol-2-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 5-amino-1,3-dihydro-benzimidazol-2-one and 2-chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone (Example 233a) according to the method described in Example 206. Melting Point: 201-205° C. (diethylether)

Sources & evidence

ORD record
ord-34187299672f4cd3adf735cb8fb3a99f
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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