HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-hydroxybenzimidazole → 5-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-1,3-dihydro-benzoimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-hydroxybenzimidazole | HCID 66765 | — |
| Reactant | 2-Chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone | HCID 69100011 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-1,3-dihydro-benzoimidazol-2-one | HCID 69100390 | — |
Reaction Steps
The title compound is prepared from 5-amino-1,3-dihydro-benzimidazol-2-one and 2-chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone (Example 233a) according to the method described in Example 206. Melting Point: 201-205° C. (diethylether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435744B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-34187299672f4cd3adf735cb8fb3a99f |
| Source note | uspto-grants-2008_10 |