P-Anisidine → 1-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-(4-methoxy-phenylamino)-ethanone

HRID 2115152Notes

Reaction equation

HRID 2115152 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:26])[CH2:14][NH:15][C:16]3[CH:25]=[CH:24][C:19]4NC(=O)O[C:18]=4[CH:17]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH3:29][O:30]C1C=CC(N)=CC=1>C(OCC)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:26])[CH2:14][NH:15][C:16]3[CH:25]=[CH:24][C:19]([O:30][CH3:29])=[CH:18][CH:17]=3)[CH2:9][CH2:8]2)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 690999906-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-3h-benzoxazol-2-one

Product 1

HCID 691005641-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-2-(4-methoxy-phenylamino)-ethanone

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The title compound is prepared from 2-chloro-1-[4-(4-chloro-phenoxy)-piperidin-1-yl]-ethanone (Example 233) and 4-methoxy-aniline according to the method described in Example 206. Melting Point: 127-130° C. (diethylether)

Sources & evidence

ORD record
ord-1e8cf7ab1ca34ce5878ba2e16650b419
Source dataset
uspto-grants-2008_10
Patent number
US07435744B2

Reaction notes

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