2-Thiophenecarboxaldehyde → HCID 11188998, compound

HRID 2115201Notes

Reaction equation

HRID 2115201 reaction equation
CO[C:3]1[CH:4]=[C:5]([C:9]([C:18]2[CH:22]=[CH:21][S:20][CH:19]=2)=[C:10]2[CH2:16][CH:15]3[NH:17][CH:12]([CH2:13][CH2:14]3)[CH2:11]2)[CH:6]=[CH:7][CH:8]=1.[S:23]1[CH:27]=[CH:26][CH:25]=[C:24]1[CH:28]=O.CC1C=CC=CC=1[CH:33]=[O:34]>>[CH3:33][O:34][C:8]1[CH:7]=[CH:6][C:5]([C:9]([C:18]2[CH:22]=[CH:21][S:20][CH:19]=2)=[C:10]2[CH2:16][CH:15]3[N:17]([CH2:28][C:24]4[S:23][CH:27]=[CH:26][CH:25]=4)[CH:12]([CH2:13][CH2:14]3)[CH2:11]2)=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 73642-ThiophenecarboxaldehydeHCID 107222-MethylbenzaldehydeHCID 11266931HCID 11266931, compound

Product 1

HCID 11188998HCID 11188998, compound

Procedure

Following the protocol for Example 15, and substituting 3-[(4-methoxy-phenyl)-thiophen-3-yl-methylene]-8-aza-bicyclo[3.2.1]octane for 3-[(3-methoxy-phenyl)-thiophen-3-yl-methylene]-8-aza-bicyclo[3.2.1]octane and thiophene-2-carboxaldehyde for 2-methylbenzaldehyde the title compound was obtained; MS m/z (MH+) 408; 1H NMR 300 MHz (CDCl3) δ 6.81-7.29 (m, 10H), 3.79 (s, 2H), 3.78 (s, 3H), 3.24-3.33 (m, 2H), 2.22-2.54 (m, 4H), 1.91-2.04 (m, 2H), 1.58- 1.64 (m, 2H).

Sources & evidence

ORD record
ord-caac4793aa1a4c01b95088351880ea6a
Source dataset
uspto-grants-2008_10
Patent number
US07435822B2

Reaction notes

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