Hydrochloric Acid → HCID 178422284, compound

HRID 2115255Notes

Reaction equation

HRID 2115255 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([CH3:10])=[CH:5][C:4]=1[NH:11][C:12]([C:14]1[NH:15][N:16]=[C:17]2[C:22]=1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18]2)=O>C(O)C>[ClH:1].[CH3:9][C:7]1[C:6]([CH3:10])=[CH:5][C:4]2[NH:11][C:12]([C:14]3[NH:15][N:16]=[C:17]4[C:22]=3[CH2:21][CH2:20][NH:19][CH2:18]4)=[N:2][C:3]=2[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178428585HCID 178428585, compound

Product 1

HCID 178422284HCID 178422284, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

9 ml of an aqueous 5N hydrochloric acid solution are added to a solution of 1.7 g of tert-butyl 3-(2-amino-4,5-dimethylphenylcarbamoyl)-2,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylate in 40 ml of ethanol. After stirring at 80° C. for 60 hours, the reaction medium is brought back to ambient temperature. The precipitate formed is recovered by filtration through sintered glass and dried. 1.04 g of 3-(5,6-dimethyl-1H-benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine hydrochloride are thus obtained in the form of a beige powder, the characteristics of which are as follows:

Workup

  1. customis brought back to ambient temperature
  2. customThe precipitate formed
  3. filtrationis recovered by filtration through sintered glass
  4. customdried

Sources & evidence

ORD record
ord-022d5d9b544e43e7b2ba91105db0c94b
Source dataset
uspto-grants-2008_10
Patent number
US07435820B2

Reaction notes

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