Hydrochloric Acid → HCID 178477903, compound

HRID 2115256Notes

Reaction equation

HRID 2115256 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]([C:12]1[NH:13][N:14]=[C:15]2[C:20]=1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16]2)=O>C(O)C>[ClH:1].[NH:2]1[C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:9]=[C:10]1[C:12]1[NH:13][N:14]=[C:15]2[C:20]=1[CH2:19][CH2:18][NH:17][CH2:16]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451638HCID 178451638, compound

Product 1

HCID 178477903HCID 178477903, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

2.2 ml of an aqueous 5N hydrochloric acid solution are added to a solution of 200 mg of tert-butyl 3-(2-aminophenylcarbamoyl)-2,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine-6-carboxylate in 1 ml of ethanol. After stirring for 20 hours at 80° C., the reaction medium is brought back to ambient temperature. The insoluble material is removed by filtration through sintered glass and the filtrate is concentrated under reduced pressure. 84 mg of 3-(1H-benzimidazol-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine hydrochloride are thus obtained in the form of an orange-coloured powder, the characteristics of which are as follows:

Workup

  1. customis brought back to ambient temperature
  2. customThe insoluble material is removed by filtration through sintered glass
  3. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-00a206c335364661a231574459d2abf8
Source dataset
uspto-grants-2008_10
Patent number
US07435820B2

Reaction notes

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