Urea → HCID 178513832, compound

HRID 2115261Notes

Reaction equation

HRID 2115261 reaction equation
NC(N)=O.[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[CH2:17][CH2:16][C:15]3=[C:18]([C:21]([NH2:23])=[O:22])[NH:19][N:20]=[C:14]3[CH2:13]2)=[N:10][CH:11]=1.[F:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=1[N:35]=[C:36]=[O:37]>>[F:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:26]=1[NH:35][C:36](=[O:37])[NH:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[CH2:17][CH2:16][C:15]3=[C:18]([C:21]([NH2:23])=[O:22])[NH:19][N:20]=[C:14]3[CH2:13]2)=[N:10][CH:11]=1

Participants

4

Reactant 3

HCID 1176UreaHCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 178513831HCID 178513831, compound

Product 1

HCID 178513832HCID 178513832, compound

Procedure

The urea function is introduced onto the 6-(5-aminopyridin-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide according to the method described in Example 1, using 2-fluoro-5-(trifluoromethyl)phenyl isocyanate, and results in the obtaining of 6-{5-[3-(2fluoro-5-trifluoromethylphenyl)-ureido]pyridin-2-yl}-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide.

Workup

  1. customresults in the

Sources & evidence

ORD record
ord-77317bade12e471eba15307a0612ceb3
Source dataset
uspto-grants-2008_10
Patent number
US07435820B2

Reaction notes

Loading…