Trifluoroacetic acid → HCID 59813964, compound

HRID 2115293Notes

Reaction equation

HRID 2115293 reaction equation
C(OC([N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][N:12]([C:16](=[O:29])[CH2:17][N:18]3[C:22]([CH3:23])=[C:21]([Cl:24])[C:20]([C:25]([F:28])([F:27])[F:26])=[N:19]3)[CH2:13]2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[Cl:24][C:21]1[C:20]([C:25]([F:28])([F:26])[F:27])=[N:19][N:18]([CH2:17][C:16]([N:12]2[CH2:13][CH:14]3[CH:10]([CH2:9][NH:8][CH2:15]3)[CH2:11]2)=[O:29])[C:22]=1[CH3:23]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59813972HCID 59813972, compound

Product 1

HCID 59813964HCID 59813964, compoundYield 99%

Procedure

A mixture of compound 6 (146 mg) and trifluoroacetic acid (2 mL) was stirred at room temperature for 30 min and concentrated in vacuo to provide the title compound 7 as a pale yellow oil (111 mg, 99%). LCMS: Rf: 0.612 min, M+H+: 303.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b1da1a70c2f84dfdb8e95519c444b3e2
Source dataset
uspto-grants-2008_10
Patent number
US07435831B2

Reaction notes

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