p-Toluidine → 2-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid p-tolylamide

HRID 2115385Notes

Reaction equation

HRID 2115385 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[CH:6][CH:7]=1.[F:9][C:10]([F:28])([F:27])[C:11]([N:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][C:17]([S:23](Cl)(=[O:25])=[O:24])=[CH:18][CH:19]=2)[CH2:14]1)=[O:12]>>[C:2]1([CH3:1])[CH:7]=[CH:6][C:5]([NH:8][S:23]([C:17]2[CH:16]=[C:15]3[C:20]([CH2:21][CH2:22][N:13]([C:11](=[O:12])[C:10]([F:28])([F:9])[F:27])[CH2:14]3)=[CH:19][CH:18]=2)(=[O:24])=[O:25])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7813p-ToluidineHCID 113249022-(Trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Product 1

HCID 38128732-(2,2,2-Trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid p-tolylamide

Procedure

prepared by reaction of p-tolylamine with 2-(2,2,2-trifluoro-acetyl)-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl chloride

Sources & evidence

ORD record
ord-e5296a426d7e4003bab5d377d7c37c1a
Source dataset
uspto-grants-2008_10
Patent number
US07435815B2

Reaction notes

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