N-(pyridin-2-ylmethyl)ethanamine → HCID 11754828, compound

HRID 2115557Notes

Reaction equation

HRID 2115557 reaction equation
C1C2C(=CC=C(S(N(CC(O)=O)C3C=CC(C)=CC=3)(=O)=O)C=2)CCN1.C(NCC1C=CC=CN=1)C.[CH2:36]([N:38]([CH2:65][C:66]1[CH:71]=[CH:70][CH:69]=[CH:68][N:67]=1)[C:39](=[O:64])[CH2:40][N:41]([S:49]([C:52]1[CH:61]=[C:60]2[C:55]([CH2:56][CH2:57][N:58](C=O)[CH2:59]2)=[CH:54][CH:53]=1)(=[O:51])=[O:50])[C:42]1[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=1)[CH3:37]>C(O)=O>[CH2:36]([N:38]([CH2:65][C:66]1[CH:71]=[CH:70][CH:69]=[CH:68][N:67]=1)[C:39](=[O:64])[CH2:40][N:41]([S:49]([C:52]1[CH:61]=[C:60]2[C:55]([CH2:56][CH2:57][NH:58][CH2:59]2)=[CH:54][CH:53]=1)(=[O:51])=[O:50])[C:42]1[CH:47]=[CH:46][C:45]([CH3:48])=[CH:44][CH:43]=1)[CH3:37]

Participants

5

Reactant 3

HCID 4723804N-(pyridin-2-ylmethyl)ethanamineHCID 66885820N-(4-Methylphenyl)-N-[(1,2,3,4-tetrahydro-7-isoquinolinyl)sulfonyl]glycineHCID 86615721HCID 86615721, compound

Product 1

HCID 11754828HCID 11754828, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

prepared by reaction of [(1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl)-p-tolyl-amino]-acetic acid with ethyl-pyridin-2-ylmethyl-amine; due to the presence of formic acid in the eluent of the HPLC chromatography the product contained considerable amounts of N-ethyl-2-[(2-formyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonyl)-p-tolyl-amino]-N-pyridin-2-ylmethyl-acetamide (LC-MS: rt=0.77 min, 507 (M+1, ES+))

Sources & evidence

ORD record
ord-c0133d9ba79643baa6342751f7e70d76
Source dataset
uspto-grants-2008_10
Patent number
US07435815B2

Reaction notes

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