Methylamine → HCID 87774289, compound

Participants

Reaction Steps

A 40% aqueous solution of methylamine (0.8 ml) is added to a solution of methyl (E)-2-[2-(4-cyclopropylmethoxy-3,5-dichlorophenoxymethyl)-phenyl]-2-methoxyiminoacetate (compound nr.2; 0.88 g; 2 mmoles) in DMF (2 ml) and methanol (4 ml). The mixture is kept under stirring for 2 hours at room temperature, diluted with water (40 ml) and an extraction is effected with ethyl acetate (3×25 ml). The organic phases are joined, washed with water (2×20 ml), dried with sodium sulfate and concentrated at reduced pressure. 0.8 g of the product (thick oil) are obtained, which do not require further purification.

Provenance & Evidence