Methylamine → HCID 87774289, compound

HRID 2115582Notes

Reaction equation

HRID 2115582 reaction equation
[CH3:1][NH2:2].[CH:3]1([CH2:6][O:7][C:8]2[C:29]([Cl:30])=[CH:28][C:11]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3/[C:20](=[N:25]\[O:26][CH3:27])/[C:21]([O:23]C)=O)=[CH:10][C:9]=2[Cl:31])[CH2:5][CH2:4]1>CN(C=O)C.CO.O>[CH:3]1([CH2:6][O:7][C:8]2[C:29]([Cl:30])=[CH:28][C:11]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3/[C:20](=[N:25]\[O:26][CH3:27])/[C:21]([NH:2][CH3:1])=[O:23])=[CH:10][C:9]=2[Cl:31])[CH2:5][CH2:4]1

Participants

6

Reactant 2

HCID 6329MethylamineHCID 140509025HCID 140509025, compound

Product 1

HCID 87774289HCID 87774289, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A 40% aqueous solution of methylamine (0.8 ml) is added to a solution of methyl (E)-2-[2-(4-cyclopropylmethoxy-3,5-dichlorophenoxymethyl)-phenyl]-2-methoxyiminoacetate (compound nr.2; 0.88 g; 2 mmoles) in DMF (2 ml) and methanol (4 ml). The mixture is kept under stirring for 2 hours at room temperature, diluted with water (40 ml) and an extraction is effected with ethyl acetate (3×25 ml). The organic phases are joined, washed with water (2×20 ml), dried with sodium sulfate and concentrated at reduced pressure. 0.8 g of the product (thick oil) are obtained, which do not require further purification.

Workup

  1. extractionan extraction
  2. washwashed with water (2×20 ml)
  3. dry with materialdried with sodium sulfate
  4. concentrationconcentrated at reduced pressure

Sources & evidence

ORD record
ord-ccbaba96f52e4651a1300ad73a10fe65
Source dataset
uspto-grants-2008_10
Patent number
US07435844B2

Reaction notes

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