反应详情

In a similar manner to Step 1 of Example 227, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0951 g, 0.206 mmol) was dissolved in acetonitrile (4.0 mL), and the solution was treated with triethylamine (0.0860 mL, 0.618 mmol) and 3-thiophenesulfonyl chloride (0.0754 g, 0.412 mmol) to obtain 4-(3-thiophenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0796 g, yield 64%).