4-(Tert-butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one → 1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

HRID 2115604Notes

Reaction equation

HRID 2115604 reaction equation
C([SiH2][O:6][C:7](C)(C)[CH:8]1[CH2:12][N:11]([CH:13]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:10](=[O:20])[C:9]1([CH3:22])[CH3:21])(C)(C)C>Cl.CO>[CH:13]1([N:11]2[CH2:12][CH:8]([CH2:7][OH:6])[C:9]([CH3:21])([CH3:22])[C:10]2=[O:20])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

Participants

4

Reactant 1

HCID 1317270964-(Tert-butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one

Product 1

HCID 666652881-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 887MethanolSolvent

Procedure

Two drops of 12M HCl was added to a solution of Example 1D (75 mg, 0.21 mmoles) in methanol (1.25 mL) and stirred for one hour at room temperature. The solvent was evaporated in vacuo to provide the title compound as a colorless oil.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-5164c17e486c4ceca30c7f6b8155cce0
Source dataset
uspto-grants-2008_10
Patent number
US07435833B2

Reaction notes

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