Hydrochloric Acid → HCID 178479166, compound

HRID 2115685Notes

Reaction equation

HRID 2115685 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[OH:30])=[CH:8][C:9]=2[CH:11]2[CH2:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[NH:4][N:3]=1.[ClH:31]>O1CCOCC1>[ClH:31].[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[OH:30])=[CH:8][C:9]=2[CH:11]2[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]2)[NH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451847HCID 178451847, compound

Product 1

HCID 178479166HCID 178479166, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution tert-butyl 3-[3-amino-6-(2-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-1-piperidinecarboxylate (0.075 g, 0.183 mmol) in 1,4-dioxane (3 mL) was added 4N HCl in 1,4-dioxane (3 mL). The mixture was stirred at room temperature for 12 hrs. The resulting solid was collected with filtration to give 2-[3-amino-4-(3-piperidinyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]phenol hydrochloride. (0.062 g, yield; 98%)

Workup

  1. filtrationThe resulting solid was collected with filtration

Sources & evidence

ORD record
ord-d5f17048534944698e8f8a899f524727
Source dataset
uspto-grants-2008_10
Patent number
US07435743B2

Reaction notes

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