Hydrochloric Acid → HCID 136342442, compound

HRID 2115695Notes

Reaction equation

HRID 2115695 reaction equation
C([C:5]1[C:10]([C:11]2[CH:16]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[O:23]CC3C=CC(OC)=CC=3)[N:14]=[C:13]([NH2:33])[C:12]=2[CH2:34][OH:35])=[CH:9][CH2:8][CH2:7][N:6]=1)(C)(C)C.[ClH:36]>O1CCOCC1>[ClH:36].[NH2:33][C:13]1[N:14]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[OH:23])[CH:16]=[C:11]([C:10]2[CH2:5][NH:6][CH2:7][CH2:8][CH:9]=2)[C:12]=1[CH2:34][OH:35]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727101HCID 131727101, compound

Product 1

HCID 136342442HCID 136342442, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-butyl 2′-amino-3′-(hydroxymethyl)-6′-{2-[(4-methoxybenzyl)oxy]phenyl}-5,6-dihydro-3,4′-bipyridine-[(2H)-carboxylate (25.0 mg, 0.05 mmol) was treated with 2N HCl in dioxane (4.0 mL) overnight at room temperature. The resulting solid was collected by filtration, washed with ether and dried under reduced pressure to give 2-[6′-amino-5′-(hydroxymethyl)-1,2,5,6-tetrahydro-3,4′-bipyridin-2′-yl]phenol hydrochloride. (14 mg, yield 87%)

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-d88b6c4cda9447b3a4a2703a17e1da5a
Source dataset
uspto-grants-2008_10
Patent number
US07435743B2

Reaction notes

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