Hydrochloric Acid → HCID 136342470, compound

HRID 2115703Notes

Reaction equation

HRID 2115703 reaction equation
CC([C:5]1(C(C)(C)C)[CH:10]([C:11]2[C:20]3[CH2:19][O:18][CH2:17][NH:16][C:15]=3[N:14]=[C:13]([C:21]3[C:26]([O:27]CC4C=CC(OC)=CC=4)=[CH:25][CH:24]=[CH:23][C:22]=3[O:37][CH2:38][CH:39]3[CH2:41][CH2:40]3)[CH:12]=2)[CH2:9][CH2:8][CH2:7][N:6]1C([O-])=O)(C)C.[ClH:49]>O1CCOCC1>[ClH:49].[CH:39]1([CH2:38][O:37][C:22]2[C:21]([C:13]3[CH:12]=[C:11]([CH:10]4[CH2:9][CH2:8][CH2:7][NH:6][CH2:5]4)[C:20]4[CH2:19][O:18][CH2:17][NH:16][C:15]=4[N:14]=3)=[C:26]([OH:27])[CH:25]=[CH:24][CH:23]=2)[CH2:40][CH2:41]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22258986HCID 22258986, compound

Product 1

HCID 136342470HCID 136342470, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a stirred solution of 1,1-dimethylethyl(tert-butyl)-3-{7-[2-[(cyclopropylmethyl)oxy]-6-({[4-(methyloxy)phenyl]methyl}oxy)phenyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-5-yl}-1-piperidinecarboxylate (0.050 g, 0.083 mmol) in 1,4-Dioxane was added 4N HCl in 1,4-dioxane (2.000 mL). The mixture was stirred at room temperature for 6 hrs. The reaction mixture was concentrated under reduced pressure. The resulting residue was washed with acetonitrile to give 3-(cyclopropylmethoxy)-2-[5-(3-piperidinyl)-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-7-yl]-phenol hydrochloride as a colorless solid (0.033 g, yield; 95%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washThe resulting residue was washed with acetonitrile

Sources & evidence

ORD record
ord-f26091be66d041f994f671e59239b1e8
Source dataset
uspto-grants-2008_10
Patent number
US07435743B2

Reaction notes

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