HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-[6-(6,7-Dimethoxy(4-quinolyloxy))(2-naphthyl)](phenylmethoxy)carboxamide → 6-(6,7-Dimethoxy-4-quinolyloxy)-2-naphthylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-[6-(6,7-Dimethoxy(4-quinolyloxy))(2-naphthyl)](phenylmethoxy)carboxamide | HCID 59813732 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(6,7-Dimethoxy-4-quinolyloxy)-2-naphthylamine | HCID 67520555 | — |
Reaction Steps
A mixture of N-[6-(6,7-dimethoxy(4-quinolyloxy))(2-naphthyl)](phenylmethoxy)carboxamide (Step b, 170 mg, 0.35 mmol) and Pd/C (17 mg, 10%, Aldrich) in 60 mL of EtOAc was stirred at RT under H2 balloon for 16 h. The mixture was filtered through a Celite® pad. The filtrate was concentrated in vacuo to give the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 347.0 (M+1). Mass Calc'd for C21H18N2O3: 346.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435823B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-e9f014b3d8d94dab974e22d735a2cb8a |
| Source note | uspto-grants-2008_10 |