Trimethylsilyl iodide → HCID 11413493, compound

HRID 2116218Notes

Reaction equation

HRID 2116218 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:15]3[O:14][CH:13]([CH2:16][NH:17]C(=O)OCC4C=CC=CC=4)[CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH:2]=1.C[Si](I)(C)C>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:15]3[O:14][CH:13]([CH2:16][NH2:17])[CH2:12][C:11]=3[CH:10]=[CH:9][CH:8]=2)[CH:2]=1

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 86599164HCID 86599164, compound

Product 1

HCID 11413493HCID 11413493, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared (0.172 g, 78%) following the general procedure of Example 129 as a light yellow solid, hydrochloride salt from (+)-benzyl {[7-pyridin-3-yl-2,3-dihydro-1-benzofuran-2-yl]methyl}carbamate (0.33 g, 0.91 mmol) and trimethylsilyl iodide (0.73 g, 3.64 mmol). [α]D25=−20.4 (c 10.0 in methanol); mp 168-171° C.

Sources & evidence

ORD record
ord-422fb3d2465a42c588d6a0f5e121a4df
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

Loading…