Cyclobutylamine → HCID 11484631, compound

HRID 2116231Notes

Reaction equation

HRID 2116231 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([Cl:30])[CH:20]=[C:21]([C:22]4[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=4[CH3:29])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH:31]1([NH2:35])[CH2:34][CH2:33][CH2:32]1>>[Cl:30][C:19]1[CH:20]=[C:21]([C:22]2[C:27]([CH3:28])=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:29])[C:15]2[O:14][CH:13]([CH2:12][NH:35][CH:31]3[CH2:34][CH2:33][CH2:32]3)[CH2:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 86599257HCID 86599257, compound

Product 1

HCID 11484631HCID 11484631, compound

Procedure

The title compound was prepared (0.027 g, 21%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-([5-chloro-7-(2,6-dimethylphenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.15 g, 0.338 mmol) and cyclobutylamine (0.49 g, 6.77 mmol). mp 203-205° C.

Sources & evidence

ORD record
ord-8b58a8df0c084cb1b2353149c5cb86b0
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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