HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-methyl-1-[7-(2-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (+/-)-[7-(2-Fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate | HCID 86599085 | — |
| Product | N-methyl-1-[7-(2-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine | HCID 69108552 | — |
Reaction Steps
The title compound was prepared (0.147 g, 66%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(2-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.300 g, 0.753 mmol) and methylamine (0.92 g, 29.5 mmol). mp 148-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435837B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-bdcb048282f342a691462bc5b9a45b9b |
| Source note | uspto-grants-2008_10 |