Methylamine → N-methyl-1-[7-(2-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine

HRID 2116299Notes

Reaction equation

HRID 2116299 reaction equation
CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[CH:19][CH:20]=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=4[F:28])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:29][NH2:30]>>[CH3:29][NH:30][CH2:12][CH:13]1[CH2:17][C:16]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[F:28])[C:15]=2[O:14]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 86599085(+/-)-[7-(2-Fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate

Product 1

HCID 69108552N-methyl-1-[7-(2-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methanamine

Procedure

The title compound was prepared (0.147 g, 66%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(2-fluorophenyl)-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.300 g, 0.753 mmol) and methylamine (0.92 g, 29.5 mmol). mp 148-150° C.

Sources & evidence

ORD record
ord-bdcb048282f342a691462bc5b9a45b9b
Source dataset
uspto-grants-2008_10
Patent number
US07435837B2

Reaction notes

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