Methylamine → HCID 15941780, compound

HRID 2116335Notes

Reaction equation

CC1C=CC(S(O[CH2:12][CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([F:31])[CH:20]=[C:21]([C:22]4[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=4[O:29][CH3:30])[C:15]=3[O:14]2)(=O)=O)=CC=1.[CH3:32][NH2:33]>>[Cl:28][C:26]1[CH:25]=[CH:24][C:23]([O:29][CH3:30])=[C:22]([C:21]2[C:15]3[O:14][CH:13]([CH2:12][NH:33][CH3:32])[CH2:17][C:16]=3[CH:18]=[C:19]([F:31])[CH:20]=2)[CH:27]=1

Participants

Reactant 2

HCID 6329Methylamine

HCID 86599301HCID 86599301, compound

Product 1

HCID 15941780HCID 15941780, compound

Procedure

The title compound was prepared (0.62 g, 38%) following the general procedure of Example 390 as a white solid, hydrochloride salt from (±)-[7-(5-chloro-2-methoxyphenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl 4-methylbenzenesulfonate (0.21 g, 0.45 mmol) and methylamine (0.139 g, 4.5 mmol). mp 189-190° C.

Sources & evidence

ORD record: ord-4e18cef0610f4b7b811e5127ef3d92a5
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07435837B2

Reaction notes

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